4.1 Remuneration approach

Pursuant to art. 25 of the Articles of Association, the compensation of the members of the Board of Directors (including the Chair) is determined by the entire Board of Directors based on the proposal of the RNC and subject to and within the limits of the aggregate maximum amounts approved by the general meeting. According to section 4(b) of the Organizational Regulations, the Chair is required to abstain from the deliberation and decision-making about their own compensation. The compensation consists of fixed compensation elements and may comprise variable compensation elements. The fixed compensation includes a fixed base fee and fixed fees for chair positions and memberships in Board committees or for roles of the Board of Directors as well as potentially a lump sum compensation for expenses (if applicable), which are determined by the full Board of Directors based on the proposal of the RNC, subject to and within the limits of the aggregate maximum amounts approved by the general meeting.

Any variable compensation comprises performance-related compensation elements and financial instruments (e.g., performance stock units (PSU)) and depends on the achievement of strategic and / or financial targets set in advance by the Board of Directors over the course of a performance period defined by the Board of Directors. The compensation is awarded in cash, in the form of shares in the Company and other benefits. Where the compensation is paid in whole or in part in shares or financial instruments, the Board of Directors determines the grant conditions as well as any restriction periods and forfeit conditions.

Currently, members of the Board of Directors only receive fixed compensation elements, of which at least half are payable in shares and the remainder in cash. Board members have the option of electing to be paid up to 100% of their fixed fee in shares. For Board members electing to receive more than 50% of their fixed fee in shares, the shares exceeding the 50% portion will be granted at a discount of 20% to market price.⁹ All shares received as part of the Board’s remuneration are subject to a three-year blocking period from the date of grant. The cash and share compensation are paid out on a quarterly basis. We believe that the share-based component strengthens the alignment of the Board of Directors’ interests with those of our shareholders as well as further incentivizes the members of the Board of Directors to drive PolyPeptide’s success.

In 2025, the allocated shares were sourced from the Company’s treasury shares. During the period under review, there were no payments to pension funds or similar institutions for the members of the Board of Directors.

Below is an overview of the current remuneration framework for the Board of Directors.

Table 4:

Remuneration framework for the Board of Directors(in CHF)

If a Board member resigns before completion of the respective term of office (i.e., mid-term), such member is entitled to the respective pro-rata compensation earned up to and including the resignation date, and any compensation already received in excess of the pro-rata entitlement is to be transferred back to the Company.

Pursuant to art. 27 of the Articles of Association, expenses that are not covered by the lump sum compensation for expenses (if applicable) pursuant to PolyPeptide’s expense regulations are reimbursed against presentation of the relevant receipts. Amounts paid for expenses actually incurred do not need to be approved by the general meeting.

4.2Compensation of the Board of Directors

The structure and remuneration components of the members of the Board of Directors did not change in 2025 compared to 2024. However, the total compensation of the Board of Directors decreased by 2.5% for the year ended 31 December 2025 as compared to 31 December 2024 due to the slightly different composition of the Board of Directors during the respective years.

The following tables show the compensation of the Board of Directors for the period from 1 January 2025 to 31 December 2025 (Table 5) and from 1 January 2024 to 31 December 2024 (Table 6). In each of these periods, the Board did not receive a lump sum for expenses; rather, any expenses incurred were reimbursed against the presentation of the relevant receipts.

Reconciliation of compensation to shareholder resolutions

For the term to the AGM 2026, the AGM 2025 approved a maximum aggregate amount of fixed compensation for the Board of Directors of CHF 1,600,000 (including all employee and employer social security contributions). For the term to the AGM 2025, the AGM 2024 approved a maximum aggregate amount of fixed compensation for the Board of Directors of CHF 1,600,000 (including all employee and employer social security contributions).

Table 7 shows the reconciliation between the compensation that has been / will be paid / granted for the respective term of office and the maximum aggregate amount approved by the general meeting:

4.3Loans, credits and related-party compensation

In accordance with art. 28 of the Articles of Association, no loans or credits were directly or indirectly granted or outstanding as at 31 December 2025 or 31 December 2024, respectively, to current members of the Board of Directors. In addition, no loans or credits were directly or indirectly granted or outstanding as at 31 December 2025 or 31 December 2024, respectively, to former members of the Board of Directors.

For the years ended 31 December 2025 and 31 December 2024, respectively, no compensation was directly or indirectly paid or granted to persons closely associated with current or former members of the Board of Directors. In addition, no loans or credits were directly or indirectly granted or outstanding as at 31 December 2025 or 31 December 2024, respectively, to persons closely associated with current or former members of Board of Directors.

For the related party transactions, refer to note 22 “Related parties” of the consolidated financial statements in the Financial Report 2025.